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The research team uses the calcitonin knockout genetic model, the GPR37 gene knocks out the animal model, verifying the role of osteocalcocalcin to regulate the differentiation of the central nervous system of the central nervous system and myeline, which is based on myellarin. Peripheral potential targets have provided experimental basis for the treatment of neutrophils. For a long time, people believe that the bones are only a organ, which has been supported and protective. However, in the past 20 years, gradually studies have found that the bones can also be used as a secretory organ, through the secretion of different bone source factors, other than the bone The organ has an impact on the central nervous system, the immune system, energy metabolism, and the like. On October 22nd, the latest research results of the Brain Cognition of Shenzhen Advanced Technology Research Institute of the Chinese Academy of Sciences, the latest research results of Li Xiang team, the Brain Diseases, published in the \”Science Progress\”. The research team lasted 4 years, found that the key regulation of gemocalcin on the lower mitogenic cells in the central nervous system, and the new recipient of the new central function of the dominantin is defined first time, and the new recipients – g protein Coupled receptors (GPR37). Bone calcium has an important impact on myelin main components. In the brain, in addition to hundreds of millions of neuronal cells, there are also many colloidal cells that connect and support a variety of neurosumes, allocate nutrients, participate in repair and phagocytosis, and less epitonal cells are Forming key cells of the center nervous system myelin. As a key cell of the center nervous system, less epithelial cells have a very critical role in maintaining neuronal function, forming an insulating myelin structure, and assisting biocatecress’s jumping efficient delivery has a critical role. The function abnormality of less epitonal cells may cause the myelin structure to be damaged, resulting in myelin lesions and neuronal injury and causing nervous system dysfunction, causing a series of nervous system or mental illness, such as multiple sclerosis. At the beginning of the study, the research team exploded the mice of baconcin gene, and found that after immunostaining, protein hybridization, electron microscopy, when the mice were knocking out of the calcitonin gene, the myelin thickness of its neuronal cells Increased, researchers thus confirmed that the primary constituent component of myelin on myelin had an important impact on myelin, and further found that the deletion of bonecetin will affect less epithelial cell differentiation and myelin. Function. \”Myelin gradually matures with the development of the human body, the myelin is too thick or too thin, and it is easy to lead to moving disorders, posture abnormalities, perceptions, communication and behavioral disorders, intellectual development and other diseases. When the human body is running upright, walking, sit down, running, etc., to a certain extent, to a certain extent, to a certain extent, in turn, affect the differentiation function of less epitocomy cells in myelin, and have a certain regulation of central nervous system. Li Xiang said. What is the \”signal receiver\” \”signal receiver\” to find the neurocalcin regulatory central nerve receiving the calcitonin signal, and play a role in the central nervous system? Further exploreThe bone calcitin is combined with the receptor to affect less eglastic cells. The research team uses RNA gene sequencing comparison of RNA expression in mice and wild mice knockout mice, for the first time, GPR37 is New receptors in the center nervous system in the central nervous system. In a long history of human science, many scientists have made unremitting efforts to establish a human genome library, which has a \”orphan receptor\” that is discovered by scientists, but it is unable to define its role and matching substance. This includes GPR37. In the verification experiment, the research team uses the calcixin knockout genetic model, the GPR37 gene knockout animal model, through the integration of electron microscopy, immunostain, behavioral analysis, etc., the calcitonin can be adjusted by GPR37 to regulate the central nervous The role of system less gelocyte differentiation and myelinization, which provides experimental basis for the treatment of neuttivine as a peripheral potential target. \”We use various gene knockout animal models and use different research methods, including key electron microscopy, immunostain, RNA sequencing, etc. Under the means, the important results of this study were verified. \”Li Xiang said. Since the past, scientists have relentlessly explored the effects of baconcin on the central nervous system. For example, in 2013, the study of Frank Oili, etc., US Columbia found that bone calcium can act on neurons through blood brain barriers, regulating the central nervous system, and impact brain cognitive memory function. However, the specific mechanisms currently regulating osteogenic organs, especially the central nervous system function is not very clear. The research team first defines the new receptors in the adjustment of the central nervous system function. By deeply exploiting the intrinsic regulatory mechanism of osteocalcin in the central nervous system, it provides theoretical basis for exploring the new measures to maintain nervous system function from adjustment bone function and osteogenic factor angle from the perspective of regulatory bone function and orthopedic factor angle. It provides a scientific basis for clinical intervention strategies and new targets for related nervous system diseases. (Liu Chuan)

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